Description
AOD-9604 is a research peptide corresponding to amino acids
176–191 of the human growth hormone sequence — the C-terminal fragment associated with
lipid metabolism. Published studies report that it modulates lipid and glucose metabolism
pathways without influencing IGF-1 activity, acting primarily through β-adrenergic and
AMPK-related mechanisms. It is used in metabolic and adipocyte-differentiation research to
investigate downstream energy-regulation signalling.
The sections below summarise findings reported in published preclinical and early-stage literature. They describe what has been observed in study models, not outcomes offered to any purchaser.
Areas of Research Interest
1. Lipid metabolism pathways
- Studied for stimulation of lipolysis in adipocyte models
- Investigated for inhibition of lipogenesis
- Examined for regional differences in adipose response
2. Separation from the growth-hormone axis
A central research question is how far the lipid-metabolism signalling of this fragment can be
separated from growth hormone’s other actions. Published studies report that, unlike HGH,
AOD-9604 does not:
- Raise IGF-1
- Produce growth effects on organs
- Reduce insulin sensitivity
- Cause fluid retention
3. Energy substrate handling
- Studied for fatty-acid utilisation as an energy substrate
- Examined for markers of metabolic efficiency
- Reported not to disturb normal glucose handling in the available studies
4. Cartilage and connective tissue models
- Investigated in osteoarthritis models for effects on cartilage
- Studied for markers of joint tissue integrity
5. Tolerability in the published record
In the clinical research literature AOD-9604 is reported to show high tolerability, minimal
adverse effects, no endocrine disruption and no suppression of endogenous growth hormone
production.
6. Mechanistic comparisons drawn in the literature
- versus HGH — HGH acts broadly across growth, lipid and hormonal
pathways; AOD-9604 is studied for lipid-metabolism signalling in isolation - versus tesamorelin — tesamorelin raises endogenous growth hormone;
AOD-9604 acts without growth-hormone stimulation - versus 5-Amino-1MQ — AOD-9604 is studied for lipid-breakdown
signalling, 5-Amino-1MQ for storage capacity at the cellular level
References
- Heffernan MA et al., Eur J Endocrinol, 2001;144:511–517
- Ng FM et al., Drug Dev Res, 2000;51:63–71
- Ng FM et al., Metabolism, 2002;51(12):1739–1743
Handling and Storage
Lyophilised powder. Store the sealed vial refrigerated and protected from light. To be handled
only by trained laboratory personnel in an appropriate research setting.
Research Use Only
This product is sold exclusively as a research chemical for in-vitro laboratory investigation by qualified researchers. It is not a drug, not a dietary supplement, and not intended for human or veterinary consumption, diagnostic use, or any form of therapeutic application. No statement on this page should be read as medical advice or as a claim that this compound treats, prevents, or cures any condition. Findings referenced above are drawn from published preclinical and clinical literature and are provided for scientific reference only.
Reviews
There are no reviews yet.