Semax 10mg

Description

Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) derived from the ACTH(4-10) fragment. It is widely used in research investigating neurotrophic and nootropic signaling via modulation of BDNF, TrkB, and neurogenic transcription factors such as NGF and GAP-43. Experimental data indicate its capacity to affect redox balance, neuronal plasticity, and dopaminergic regulation in central nervous system models.

Overview

Semax is a synthetic peptide widely studied for its neuroprotective and nootropic properties. This heptapeptide is an analogue of adrenocorticotropic hormone (ACTH) but lacks hormonal activity, making it a candidate of interest for a range of neurological and cognitive research applications.

Mechanism of action

Semax is believed to exert its effects by modulating the brain’s dopaminergic and serotonergic systems. It influences neurotrophins such as brain-derived neurotrophic factor (BDNF) and promotes neurogenesis, synaptic plasticity, and neuronal repair. Semax has also been shown to regulate stress-response pathways and protect neurons from oxidative stress and ischemic damage.

Research applications

• Cognitive measures: studied for effects on learning, memory retention, and focus.
• Neuroprotection: examined for its ability to safeguard neurons in conditions such as stroke and neurodegenerative disease models.
• Stroke recovery: studied for its role in recovery from ischemic stroke by enhancing blood flow and neuroplasticity.
• Stress and anxiety: exhibits anxiolytic properties and reduces stress-related behaviors in research models.
• Mood: investigated for effects on mood regulation via neurotransmitter pathways.
• Pain: investigated for its ability to reduce chronic pain and inflammation.

Key findings noted in research

• Increased BDNF expression, associated with neurogenesis and cognitive function
• Protection against oxidative stress and ischemic injury
• Investigated in the context of ADHD, anxiety, and depression
• Studied in recovery from traumatic brain injury (TBI)

Molecular profile

• Molecular formula: C37H51N9O10S
• Molecular weight: 813.92 g/mol

References

• Ashmarin IP et al., Neurosci Behav Physiol, 1998;28(3):341–348
• Ashmarin IP et al., Neurochem J, 2005;39(1):36–44
• Dolotov OV et al., Brain Res Bull, 2011;85(5):327–332

This product is supplied for laboratory research use only. Most evidence comes from animal studies and early-stage research.

Research Use Only
This product is sold exclusively as a research chemical for in-vitro laboratory investigation by qualified researchers. It is not a drug, not a dietary supplement, and not intended for human or veterinary consumption, diagnostic use, or any form of therapeutic application. No statement on this page should be read as medical advice or as a claim that this compound treats, prevents, or cures any condition. Findings referenced above are drawn from published preclinical and clinical literature and are provided for scientific reference only.