IGF-1 LR3 (1 mg)

Description

What is IGF‑1 LR3?IGF‑1 LR3 (Insulin‑like Growth Factor‑1 Long Arg3) is a recombinant analogue of human IGF‑1, modified to enhance metabolic stability and receptor potency while reducing binding to IGF‑binding proteins (IGFBPs) [4]. The peptide contains the entire native 70-residue IGF‑1 sequence, with two main alterations: a glutamic acid to arginine substitution at position 3 (Arg3), and a 13-amino-acid N-terminal extension (making it “long-R3”) for sustained activity in research settings Chemical Structure of IGF‑1 LR3IGF‑1 LR3 is an 83-amino-acid polypeptide with the full sequence: MFPAMPLSSLFVNGPRTLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSAKey structural features: Arg instead of Glu at position 3, and a 13-amino-acid extension at the N-terminus [1][5]. Its formula is C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉, and the molecular weight is approximately 9,117 Da What Are the Effects of IGF‑1 LR3?Enhanced Anabolic and Mitogenic Activity: IGF‑1 LR3 demonstrates approximately 3× greater receptor potency than native IGF‑1 and sustains signaling through PI3K/Akt and MAPK pathways due to lower IGFBP binding and extended half-life (~20–30 hours).Cell Proliferation and Protein Synthesis: Promotes cell division, nitrogen retention, protein synthesis, and lean tissue mass accumulation in animal models.Tissue Regenerative Research: Used in muscle, cartilage, nerve, liver, and skin regeneration models, where it enhances nutrient uptake and supports anabolic repair processes.Metabolic Modulation: Facilitates glucose and amino acid uptake while improving insulin sensitivity under metabolic stress conditions.Atherosclerotic Plaque Stability: Helps stabilize atherosclerotic plaques by improving vascular smooth muscle phenotype and reducing plaque vulnerability.

Research Use Only
This product is sold exclusively as a research chemical for in-vitro laboratory investigation by qualified researchers. It is not a drug, not a dietary supplement, and not intended for human or veterinary consumption, diagnostic use, or any form of therapeutic application. No statement on this page should be read as medical advice or as a claim that this compound treats, prevents, or cures any condition. Findings referenced above are drawn from published preclinical and clinical literature and are provided for scientific reference only.